Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 7/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | MET | P08581 | 10/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503691 | 0.92 | PDGFRA (0.54) | PDGFRAKITKDRMETFGFR2 | |
| SCHEMBL22535169 | 0.82 | PDGFRA (0.52) | PDGFRAKITKDRMETIGF1R | |
| SCHEMBL1891970 | 0.81 | PDGFRA (0.51) | PDGFRAKITKDRMETIGF1R | |
| SCHEMBL1890461 | 0.81 | PDGFRA (0.49) | PDGFRAKITKDRMETFGFR2 | |
| SCHEMBL1897844 | 0.81 | PDGFRA (0.49) | PDGFRAKITKDRMETIGF1R | |
| SCHEMBL1892785 | 0.81 | PDGFRA (0.62) | PDGFRAKITKDRMETLCK | |
| SCHEMBL12503620 | 0.81 | PDGFRA (0.65) | PDGFRAKITKDRMETFGFR2 | |
| SCHEMBL1890556 | 0.81 | PDGFRA (0.51) | PDGFRAKITKDRMETTEK | |
| SCHEMBL1895557 | 0.81 | KDR (0.57) | PDGFRAKITKDRMETIGF1R | |
| SCHEMBL12503492 | 0.80 | PDGFRA (0.50) | PDGFRAKITKDRMETLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |