Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 7/20 | 0.41 |
| ▸ | MET | P08581 | 7/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902592 | 0.89 | KDR (0.49) | KDRAXLAURKAMETAURKB | |
| SCHEMBL12503719 | 0.88 | KDR (0.43) | KDRAXLMETFLT1PDGFRA | |
| SCHEMBL1894686 | 0.87 | KDR (0.64) | KDRAXLAURKAMETAURKB | |
| SCHEMBL1890585 | 0.84 | KDR (0.57) | KDRAXLAURKAMETAURKB | |
| SCHEMBL13627390 | 0.84 | KDR (0.49) | KDRAXLAURKAMETAURKB | |
| SCHEMBL1891016 | 0.79 | KDR (0.43) | KDRAXLAURKAMETAURKB | |
| SCHEMBL1891671 | 0.78 | KDR (0.42) | KDRAXLMETFLT1EGFR | |
| SCHEMBL5108381 | 0.76 | KDR (0.47) | KDR | |
| SCHEMBL1889354 | 0.76 | KDR (0.43) | KDRAXLAURKAMETAURKB | |
| SCHEMBL12411938 | 0.76 | KDR (0.43) | KDRAXLAURKAMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |