Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 16/20 | 0.64 |
| ▸ | KIT | P10721 | 3/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.58 |
| ▸ | STK10 | O94804 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | FLT4 | P35916 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | ABL2 | P42684 | 2/20 | 0.58 |
| ▸ | FRK | P42685 | 2/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503768 | 0.92 | KDR (0.63) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL12503740 | 0.86 | KDR (0.68) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL1892120 | 0.85 | KDR (0.76) | KDRPDGFRAKITAXLRIPK2 | |
| Hydrochloric Acid SCHEMBL4670112 | 0.85 | KDR (0.75) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL12503732 | 0.83 | KDR (0.58) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL12503783 | 0.83 | KDR (0.65) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL12503766 | 0.83 | KDR (0.75) | KDRPDGFRAKITAXLMET | |
| SCHEMBL1894464 | 0.82 | KDR (0.66) | KDRPDGFRAKITAXLRIPK2 | |
| SCHEMBL1891099 | 0.82 | PDGFRA (0.77) | KDRPDGFRAAXL | |
| SCHEMBL12502214 | 0.82 | KDR (0.56) | KDRPDGFRAKITAXLRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |