Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | HTR5A | P47898 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479798 | 1.00 | HTR2C (0.43) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL4249176 | 1.00 | HTR2C (0.43) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL4476708 | 0.80 | HTR2C (0.49) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL4474244 | 0.80 | HTR2C (0.49) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL13627318 | 0.80 | HTR2C (0.49) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL4466314 | 0.76 | POLB (0.40) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL4244437 | 0.75 | HTR2C (0.40) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL4477657 | 0.75 | HTR2C (0.40) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL13627308 | 0.75 | HTR2C (0.40) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL13627304 | 0.73 | HTR2C (0.52) | HTR2CHTR2AHTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |