⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18814891 | 0.85 | — | — | |
| SCHEMBL13759978 | 0.82 | — | — | |
| SCHEMBL18871650 | 0.82 | — | — | |
| SCHEMBL13667458 | 0.81 | — | — | |
| SCHEMBL31370776 | 0.80 | — | — | |
| SCHEMBL18272089 | 0.80 | — | — | |
| SCHEMBL14901052 | 0.79 | — | — | |
| SCHEMBL14527900 | 0.78 | KDM4E (0.35) | — | |
| SCHEMBL21615105 | 0.78 | — | — | |
| SCHEMBL21133086 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230001024-A1 | CROSS-LINKING COMPOUNDS AND METHODS OF USE THEREOF | NORTH CAROLINA STATE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| EP-3139963-B1 | CONJUGATES AND PRODRUGS FOR TREATING OF CANCER AND INFLAMMATORY DISEASES | CENTRE NAT RECH SCIENT (FR) | 2020-10-07 | — | — | EP | disclosed |
| US-9932331-B2 | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2018-04-03 | — | — | US | disclosed |
| US-20170210736-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2017-07-27 | — | — | US | disclosed |
| EP-3173408-A1 | PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL | Taisho Pharmaceutical Co., Ltd. (JP) | 2017-05-31 | — | — | EP | disclosed |
| US-20130309277-A1 | POLYMER MICELLES CONTAINING ANTHRACYCLINES FOR THE TREATMENT OF CANCER | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2013-11-21 | — | — | US | disclosed |
| EP-2359862-B1 | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents | INTEZYNE TECHNOLOGIES INC (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2359862-A1 | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents | Intezyne Technologies Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2009134984-A1 | SYNTHESIS OF HYBRID BLOCK COPOLYMERS FROM DIFLUOROACETATE AMMONIUM SALTS | INTEZYNE TECHNOLGIES INC. (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2008134731-A1 | HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS | INTEZYNE TECHNOLOGIES, INC. (US) | 2008-11-06 | — | — | WO | disclosed |