Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003589 | 0.97 | HCRTR1 (0.53) | HCRTR1HCRTR2GRM2CHRM5GRIN2B | |
| SCHEMBL12581836 | 0.93 | HCRTR1 (0.46) | HCRTR1HCRTR2GRM2CHRM5GRIN2B | |
| SCHEMBL2028806 | 0.92 | HCRTR1 (0.53) | HCRTR1HCRTR2GRM2CYP3A4 | |
| SCHEMBL2025638 | 0.92 | HCRTR1 (0.45) | HCRTR1HCRTR2GRM2CHRM5GRIN2B | |
| SCHEMBL12413546 | 0.91 | HCRTR1 (0.52) | HCRTR1HCRTR2GRM2GRIN2BCYP3A4 | |
| SCHEMBL2022984 | 0.90 | GRM2 (0.47) | HCRTR1HCRTR2GRM2CYP3A4 | |
| SCHEMBL2027900 | 0.90 | HCRTR1 (0.43) | HCRTR1HCRTR2GRM2CHRM5GRIN2B | |
| SCHEMBL2022457 | 0.86 | GRM2 (0.48) | HCRTR1HCRTR2GRM2CHRM5CYP3A4 | |
| SCHEMBL1003171 | 0.85 | CHRM5 (0.48) | HCRTR1HCRTR2GRM2CHRM5GRIN2B | |
| SCHEMBL2029663 | 0.85 | GRM2 (0.55) | HCRTR1HCRTR2GRM2CHRM5GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | HCRTR1 260/4885HCRTR2 326/4885GRM2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.