Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722460 | 0.86 | MAP2K1 (0.63) | MAP2K1MAP2K2 | |
| SCHEMBL697857 | 0.86 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL13148418 | 0.84 | MAP2K1 (0.55) | MAP2K1MAP2K2 | |
| SCHEMBL13628977 | 0.83 | MAP2K1 (0.47) | MAP2K1MAP2K2NPC1RAB9A | |
| SCHEMBL3794238 | 0.76 | MAP2K1 (0.64) | MAP2K1MAP2K2 | |
| SCHEMBL3793338 | 0.76 | MAP2K1 (0.50) | MAP2K1 | |
| SCHEMBL13148419 | 0.75 | MAP2K1 (0.56) | MAP2K1 | |
| SCHEMBL13148417 | 0.73 | MAP2K1 (0.43) | MAP2K1 | |
| SCHEMBL13148380 | 0.72 | MAP2K1 (0.51) | MAP2K1 | |
| SCHEMBL696783 | 0.72 | MAP2K1 (0.72) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NRAS, BRAF, MAP3K1 | MAP2K1 48/4885MAP2K2 38/4885NPC1 2784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.