Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | SHH | Q15465 | 1/20 | 0.65 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.65 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.65 |
| ▸ | SMO | Q99835 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018498 | 0.91 | ALB (0.65) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL12918416 | 0.87 | ALB (0.60) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1015958 | 0.87 | CYP2C9 (0.66) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL19132252 | 0.86 | ALB (0.59) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL16642302 | 0.85 | ALB (0.66) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1018130 | 0.85 | SMO (0.71) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL10029762 | 0.84 | ALB (0.74) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL2611865 | 0.84 | ALB (0.57) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL26037897 | 0.84 | ALB (0.57) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL13628641 | 0.84 | ALB (0.67) | ALBHTR1ASLC6A2PDE4AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | ALB 4881/4885HTR1A 1322/4885SLC6A2 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.