Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 20/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 18/20 | 1.00 |
| ▸ | PTGER1 | P34995 | 2/20 | 1.00 |
| ▸ | PTGER3 | P43115 | 2/20 | 1.00 |
| ▸ | PTGER2 | P43116 | 2/20 | 1.00 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 1.00 |
| ▸ | PTGER4 | P35408 | 1/20 | 1.00 |
| ▸ | PTGFR | P43088 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629406 | 1.00 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL990528 | 1.00 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL4548353 | 1.00 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL8260383 | 0.95 | PTGDR (0.90) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL12808618 | 0.93 | PTGDR (0.86) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL14401189 | 0.92 | PTGDR (0.84) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13635024 | 0.92 | PTGDR (0.84) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13176191 | 0.90 | PTGDR (0.81) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13176193 | 0.90 | PTGDR (0.81) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13629405 | 0.88 | PTGDR (0.79) | PTGDRTBXA2RPTGER1PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618979-B2 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| US-7618979-B2 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |