Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632176 | 0.88 | TP53 (0.45) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4505976 | 0.82 | F10 (0.55) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4516610 | 0.81 | TP53 (0.45) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4505254 | 0.80 | TP53 (0.47) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4516670 | 0.79 | TP53 (0.45) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4511189 | 0.79 | F10 (0.46) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4506006 | 0.79 | F10 (0.46) | TP53LMNAPOLBF10ALDH1A1 | |
| SCHEMBL4495318 | 0.79 | F10 (0.52) | TP53LMNAPOLBF10 | |
| SCHEMBL4506653 | 0.79 | F10 (0.57) | TP53F10 | |
| SCHEMBL4492727 | 0.79 | F10 (0.57) | TP53F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |