Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633120 | 0.99 | ALK (0.53) | ALKJAK2MEN1KMT2APOLB | |
| SCHEMBL13633034 | 0.93 | ALK (0.46) | ALKJAK2MEN1KMT2ACYP3A4 | |
| SCHEMBL13634075 | 0.92 | JAK2 (0.49) | ALKJAK2MEN1KMT2ACYP3A4 | |
| SCHEMBL4363391 | 0.91 | ALK (0.65) | ALKJAK2MEN1KMT2AJAK1 | |
| SCHEMBL4358080 | 0.90 | ALK (0.66) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL13633122 | 0.89 | ALK (0.45) | ALKJAK2MEN1KMT2ACYP3A4 | |
| SCHEMBL13633183 | 0.87 | ALK (0.42) | ALKJAK2JAK1TYK2FLT3 | |
| Trifluoroacetic Acid SCHEMBL4359450 | 0.86 | ALK (0.59) | ALKJAK2MEN1KMT2AJAK1 | |
| SCHEMBL13634077 | 0.86 | ALK (0.46) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL13633121 | 0.86 | ALK (0.43) | ALKJAK2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885JAK2 1/4885MEN1 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.