Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MTTP | P55157 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068495 | 0.87 | ABL1 (0.58) | ABL1 | |
| SCHEMBL12140670 | 0.82 | ABL1 (0.41) | ABL1POLBRAB9ADYRK1A | |
| SCHEMBL8997564 | 0.82 | ABL1 (0.44) | ABL1HSD17B10CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL9068371 | 0.77 | ABL1 (0.44) | ABL1 | |
| SCHEMBL9068458 | 0.77 | ABL1 (0.43) | ABL1 | |
| SCHEMBL9068602 | 0.73 | PIK3CA (0.45) | ABL1PIK3CA | |
| SCHEMBL13712078 | 0.73 | ABL1 (0.56) | ABL1 | |
| SCHEMBL9068612 | 0.72 | ABL1 (0.43) | ABL1 | |
| SCHEMBL9068601 | 0.72 | ABL1 (0.60) | ABL1 | |
| SCHEMBL13953973 | 0.72 | ABL1 (0.53) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618974-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-17 | — | — | US | disclosed |