Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.39 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.37 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 7/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAF1 | P21675 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623292 | 0.90 | JAK2 (0.50) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13633094 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13634064 | 0.85 | MAPK1 (0.38) | JAK2JAK1TYK2JAK3ALK | |
| Trifluoroacetic Acid SCHEMBL1076370 | 0.83 | JAK2 (0.44) | JAK2JAK1TYK2JAK3ALK | |
| Trifluoroacetic Acid SCHEMBL4364462 | 0.83 | JAK2 (0.44) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13633109 | 0.83 | JAK2 (0.37) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13634045 | 0.81 | JAK2 (0.37) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13633181 | 0.80 | JAK2 (0.44) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL13632987 | 0.80 | GRIN2B (0.38) | JAK2ALKMEN1CYP3A4CYP2D6 | |
| SCHEMBL13632989 | 0.79 | ALK (0.39) | JAK2JAK1TYK2JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | JAK2 1/4885JAK1 2/4885TYK2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.