Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPD | P32754 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12161424 | 0.92 | P2RY12 (0.50) | P2RY12PPARGTP53NOD1CA12 | |
| SCHEMBL12161429 | 0.85 | P2RY12 (0.51) | P2RY12PPARGTP53NOD1CA12 | |
| SCHEMBL9922358 | 0.84 | P2RY12 (0.45) | P2RY12PPARGTP53NOD1MAPT | |
| SCHEMBL12161482 | 0.83 | P2RY12 (0.40) | P2RY12PPARGMAPTLMNA | |
| SCHEMBL12161459 | 0.82 | P2RY12 (0.46) | P2RY12NOD1MAPTLMNAHPD | |
| SCHEMBL12161433 | 0.81 | P2RY12 (0.54) | P2RY12PPARGTP53NOD1MAPT | |
| SCHEMBL14228576 | 0.79 | P2RY12 (0.49) | P2RY12PPARGTP53NOD1MAPT | |
| SCHEMBL14228578 | 0.79 | P2RY12 (0.53) | P2RY12PPARGTP53NOD1MAPT | |
| SCHEMBL9922360 | 0.78 | P2RY12 (0.45) | P2RY12PPARGTP53NOD1MAPT | |
| SCHEMBL13638511 | 0.78 | P2RY12 (0.45) | P2RY12PPARGTP53NOD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |