Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.66 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635088 | 0.94 | P2RY12 (0.66) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635171 | 0.93 | P2RY12 (0.64) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635047 | 0.92 | P2RY12 (0.67) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635114 | 0.90 | P2RY12 (0.66) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635091 | 0.89 | P2RY12 (0.65) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635164 | 0.89 | P2RY12 (0.67) | P2RY12HTR3ANAMPTSMN1; SMN2TP53 | |
| SCHEMBL13635281 | 0.89 | P2RY12 (0.68) | P2RY12HTR3ASMN1; SMN2LMNATP53 | |
| SCHEMBL13635084 | 0.89 | P2RY12 (0.66) | P2RY12SMN1; SMN2LMNATP53FBP1 | |
| SCHEMBL13635077 | 0.88 | P2RY12 (0.64) | P2RY12HTR3ANAMPTSMN1; SMN2LMNA | |
| SCHEMBL13635618 | 0.88 | P2RY12 (0.68) | P2RY12HTR3ASMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |