Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635287 | 0.94 | P2RY12 (0.54) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13635630 | 0.91 | P2RY12 (0.55) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL9922499 | 0.90 | P2RY12 (0.70) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13635179 | 0.90 | P2RY12 (0.54) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13635285 | 0.89 | P2RY12 (0.63) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13635099 | 0.89 | P2RY12 (0.52) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13635629 | 0.89 | P2RY12 (0.52) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL13634873 | 0.88 | P2RY12 (0.52) | P2RY12RXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL4418832 | 0.88 | P2RY12 (0.54) | P2RY12RXFP1TP53MAPTHTR3A | |
| SCHEMBL4415315 | 0.87 | P2RY12 (0.52) | P2RY12RXFP1TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |