Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474784 | 0.85 | MAPK14 (0.66) | MAPK14CHRM5NOTUM | |
| SCHEMBL4376201 | 0.79 | MAPK14 (0.74) | MAPK14 | |
| SCHEMBL4384792 | 0.72 | MAPK14 (0.56) | MAPK14NOTUM | |
| SCHEMBL4377489 | 0.71 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL3523709 | 0.69 | MAPK14 (0.48) | MAPK14PKMKMT2A | |
| SCHEMBL4377189 | 0.69 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL4465977 | 0.68 | MAPK14 (0.57) | MAPK14NOTUM | |
| SCHEMBL4384354 | 0.67 | MAPK14 (0.53) | MAPK14NOTUM | |
| SCHEMBL4376625 | 0.67 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL4379376 | 0.67 | MAPK14 (0.72) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |