SCHEMBL13635221

SCHEMBL13635221

Bc1c(OCc2ccc(F)cc2F)cc(C)n(-c2cnc(C#N)nc2C)c1=O

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 18/20 0.49
MAPKAPK2 P49137 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29593567 0.89 MAPK14 (0.64) MAPK14
SCHEMBL5862556 0.89 MAPK14 (0.64) MAPK14
SCHEMBL13635607 0.84 MAPK14 (0.49) MAPK14MAPKAPK2
SCHEMBL3523558 0.79 MAPK14 (0.47) MAPK14
SCHEMBL13635917 0.76 MAPK14 (0.55) MAPK14
SCHEMBL5861996 0.75 MAPK14 (0.66) MAPK14
SCHEMBL29594751 0.75 MAPK14 (0.66) MAPK14
SCHEMBL4486520 0.74 MAPK14 (0.65) MAPK14
SCHEMBL29594200 0.74 MAPK14 (0.65) MAPK14
SCHEMBL5863026 0.74 MAPK14 (0.65) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP disclosed