Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384963 | 0.86 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL3527712 | 0.80 | MAPK14 (0.53) | METAP2MAPK14 | |
| SCHEMBL4386829 | 0.72 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL4385221 | 0.72 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL4384592 | 0.69 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL4376999 | 0.69 | MAPK14 (0.50) | MAPK14 | |
| SCHEMBL4379008 | 0.69 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL4376480 | 0.69 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL4478238 | 0.69 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL4390507 | 0.68 | MAPK14 (0.53) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |