SCHEMBL13635314

SCHEMBL13635314

Bc1c(OCc2ccc(F)cc2F)cc(C)n(Cc2cnc(CNCCO)cn2)c1=O

nearest known ligand 0.49

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4387510 0.78 MAPK14 (0.67) MAPK14
SCHEMBL13635309 0.78 MAPK14 (0.55) MAPK14
SCHEMBL6471625 0.78 MAPK14 (0.63) MAPK14
SCHEMBL13635594 0.78 MAPK14 (0.64) MAPK14
SCHEMBL4385192 0.78 MAPK14 (0.64) MAPK14
SCHEMBL29594116 0.78 MAPK14 (0.61) MAPK14
SCHEMBL4386899 0.78 MAPK14 (0.61) MAPK14
Hydrochloric Acid SCHEMBL6502397 0.78 MAPK14 (0.62) MAPK14
SCHEMBL4376308 0.78 MAPK14 (0.75) MAPK14
SCHEMBL4384623 0.78 MAPK14 (0.64) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP disclosed