SCHEMBL13635315

SCHEMBL13635315

Cc1cc(CCc2ccc(F)cc2F)c(Br)c(=O)n1Cc1cnc(C(=O)N(C)CCO)cn1

nearest known ligand 0.45

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29593367 0.88 MAPK14 (0.61) MAPK14
SCHEMBL4382400 0.88 MAPK14 (0.61) MAPK14
SCHEMBL13635200 0.86 MAPK14 (0.45) MAPK14
SCHEMBL3524961 0.84 MAPK14 (0.45) MAPK14
SCHEMBL4384876 0.78 MAPK14 (0.70) MAPK14
SCHEMBL4376038 0.77 MAPK14 (0.65) MAPK14
SCHEMBL13602989 0.75 MAPK14 (0.64) MAPK14
SCHEMBL3524089 0.74 MAPK14 (0.51) MAPK14
SCHEMBL4376131 0.74 MAPK14 (0.63) MAPK14
SCHEMBL29594116 0.73 MAPK14 (0.61) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP disclosed