Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376284 | 0.88 | MAPK14 (0.83) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL29594336 | 0.88 | MAPK14 (0.83) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4376230 | 0.80 | MAPK14 (0.81) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL29594285 | 0.80 | MAPK14 (0.81) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3523052 | 0.80 | MAPK14 (0.74) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3522858 | 0.79 | MAPK14 (0.76) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL29594309 | 0.78 | MAPK14 (1.00) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4382895 | 0.78 | MAPK14 (1.00) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5264986 | 0.76 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL6506012 | 0.75 | MAPK14 (0.83) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |