Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 10/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2864745 | 0.86 | MAP2K4 (0.58) | MAP2K4MAPK1MAP2K7GSK3AGSK3B | |
| SCHEMBL4338871 | 0.84 | MAP2K4 (0.43) | TTKMAP2K4MAPK1CSNK1DMAP2K7 | |
| SCHEMBL4336321 | 0.83 | MAPK1 (0.43) | TTKMAP2K4MAPK1MAP2K7GSK3A | |
| SCHEMBL2870208 | 0.83 | GSK3B (0.51) | MAP2K4MAPK1MAP2K7GSK3AGSK3B | |
| SCHEMBL4336457 | 0.82 | MAPK1 (0.50) | TTKMAP2K4MAPK1MAP2K7NTRK1 | |
| SCHEMBL2864643 | 0.81 | SMN1; SMN2 (0.56) | MAPK1CSNK1DGSK3AGSK3B | |
| SCHEMBL4335876 | 0.81 | MAPK1 (0.56) | MAPK1 | |
| SCHEMBL4336095 | 0.79 | MAPK1 (0.51) | MAP2K4MAPK1MAP2K7GSK3AGSK3B | |
| SCHEMBL4348122 | 0.79 | TAAR1 (0.49) | TTKMAPK1 | |
| SCHEMBL27558524 | 0.79 | MAP2K4 (0.54) | MAP2K4MAPK1CSNK1DMAP2K7GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |