Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 17/20 | 0.52 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729628 | 0.85 | PTPN1 (0.72) | PTPN1 | |
| SCHEMBL3745228 | 0.75 | PTPN1 (0.72) | PTPN1 | |
| SCHEMBL3742350 | 0.70 | PTPN1 (0.62) | PTPN1 | |
| SCHEMBL3735392 | 0.69 | PTPN1 (0.64) | PTPN1 | |
| SCHEMBL13870896 | 0.67 | PSMB5 (0.44) | MAPTNPSR1ALPL | |
| SCHEMBL24395080 | 0.66 | MAPT (0.43) | MAPTNPSR1ALPL | |
| SCHEMBL7039117 | 0.65 | HSD17B10 (0.46) | MAPTNPSR1ALPL | |
| SCHEMBL13870915 | 0.65 | CYP17A1 (0.38) | MAPTNPSR1ALPL | |
| SCHEMBL13989405 | 0.65 | CYP1A2 (0.53) | MAPTNPSR1ALPL | |
| SCHEMBL13298969 | 0.63 | CYP1A2 (0.55) | MAPTNPSR1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |