Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382826 | 0.92 | MAPK14 (1.00) | MAPK14ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL4376100 | 0.78 | MAPK14 (0.69) | MAPK14ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL13635877 | 0.78 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL4373903 | 0.77 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL4381707 | 0.77 | MAPK14 (0.77) | MAPK14POLBTHRB | |
| SCHEMBL4378211 | 0.77 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL4383504 | 0.77 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL3521630 | 0.76 | MAPK14 (0.71) | MAPK14ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL4392630 | 0.74 | MAPK14 (0.68) | MAPK14ALDH1A1KDM4EPKMMEN1 | |
| SCHEMBL13635286 | 0.74 | MAPK14 (0.66) | MAPK14ALDH1A1KDM4EPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |