Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376582 | 0.86 | MAPK14 (0.43) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6472178 | 0.80 | MAPK14 (0.51) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL29593340 | 0.79 | MAPK14 (0.62) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4381572 | 0.79 | MAPK14 (0.62) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4385571 | 0.79 | MAPK14 (0.45) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4389772 | 0.78 | MAPK14 (0.53) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6473916 | 0.77 | MAPK14 (0.49) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6508489 | 0.76 | MAPK14 (0.44) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6501247 | 0.73 | MAPK14 (0.50) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL3521464 | 0.73 | MAPK14 (0.48) | MAPK14ROCK2MAPK12MAPK11STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |