Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375426 | 0.91 | HRH3 (0.64) | HRH3SMN1; SMN2ALDH1A1POLBTDP1 | |
| Hydrochloric Acid SCHEMBL4375730 | 0.90 | HRH3 (0.65) | HRH3SMN1; SMN2ALDH1A1POLBTDP1 | |
| SCHEMBL14190971 | 0.88 | HRH3 (0.66) | HRH3KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL4377304 | 0.77 | HRH3 (0.97) | HRH3POLB | |
| Hydrochloric Acid SCHEMBL4382044 | 0.76 | HRH3 (1.00) | HRH3POLB | |
| SCHEMBL14218058 | 0.74 | HRH3 (0.74) | HRH3KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL4379469 | 0.73 | HRH3 (0.64) | HRH3KMT2AALDH1A1 | |
| SCHEMBL4388156 | 0.73 | HRH3 (0.64) | HRH3KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL4378095 | 0.73 | HRH3 (0.88) | HRH3POLB | |
| Hydrochloric Acid SCHEMBL4377733 | 0.72 | HRH3 (0.65) | HRH3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |