Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379229 | 0.89 | HRH3 (0.98) | HRH3 | |
| Hydrochloric Acid SCHEMBL4378570 | 0.88 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4378327 | 0.79 | HRH3 (1.00) | HRH3 | |
| Hydrochloric Acid SCHEMBL4376343 | 0.78 | HRH3 (1.00) | HRH3 | |
| Hydrochloric Acid SCHEMBL4376182 | 0.76 | HRH3 (0.80) | HRH3 | |
| SCHEMBL4379382 | 0.73 | HRH3 (0.97) | HRH3 | |
| Hydrochloric Acid SCHEMBL4380930 | 0.72 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4377286 | 0.69 | HRH3 (0.88) | HRH3 | |
| SCHEMBL318783 | 0.68 | HSD17B3 (0.67) | LMNAMAPTHPGDKMT2A | |
| Hydrochloric Acid SCHEMBL4376199 | 0.68 | HRH3 (0.90) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |