Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.55 |
| ▸ | HRH2 | P25021 | 10/20 | 0.50 |
| ▸ | HRH1 | P35367 | 10/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4388605 | 0.89 | HRH3 (0.69) | HRH3HRH2HRH1GAAMAPT | |
| Hydrochloric Acid SCHEMBL4388603 | 0.88 | HRH3 (0.71) | HRH3HRH2HRH1GAAMAPT | |
| SCHEMBL13636025 | 0.88 | HRH2 (0.50) | HRH3HRH2HRH1GAAMAPT | |
| SCHEMBL4378509 | 0.83 | HRH3 (0.71) | HRH3HRH2HRH1GAAMAPT | |
| SCHEMBL4387240 | 0.83 | HRH3 (0.53) | HRH3HRH2HRH1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4387237 | 0.82 | HRH3 (0.54) | HRH3HRH2HRH1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4378506 | 0.82 | HRH3 (0.73) | HRH3HRH2HRH1GAAMAPT | |
| SCHEMBL4389352 | 0.80 | HRH3 (0.52) | HRH3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4389348 | 0.79 | HRH3 (0.54) | HRH3SMN1; SMN2 | |
| SCHEMBL4386252 | 0.77 | HRH3 (0.54) | HRH3HRH2HRH1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |