Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12824890 | 0.84 | PRSS1 (0.64) | TDP1MAPTALDH1A1PRSS1PRSS2 | |
| SCHEMBL8860069 | 0.83 | MAPT (0.61) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL18866954 | 0.83 | MAPT (0.61) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL22905073 | 0.79 | TDP1 (0.42) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL23592021 | 0.78 | TSHR (0.50) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL13495684 | 0.78 | TDP1 (0.61) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL284729 | 0.78 | TDP1 (0.73) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL20836577 | 0.78 | TDP1 (0.55) | TDP1MAPTALDH1A1CASP1PRSS1 | |
| SCHEMBL18773955 | 0.77 | HDAC1 (0.52) | TDP1MAPTALDH1A1PRSS1PRSS2 | |
| SCHEMBL13783388 | 0.76 | MAPT (0.76) | TDP1MAPTALDH1A1CASP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242385-B1 | CYTOKINE, ESPECIALLY TNF-ALPHA, INHIBITORS | PHARMACOPEIA INC (US) | 2009-11-25 | — | — | EP | disclosed |