SCHEMBL13636374

SCHEMBL13636374

CC1CCC(c2ccc(-c3ccc(-c4cc(F)cc(F)c4)c(F)c3)cc2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.42
CYP3A4 P08684 3/20 0.41
CYP2C9 P11712 2/20 0.41
APP P05067 2/20 0.41
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
FASN P49327 1/20 0.39
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
TNKS O95271 4/20 0.33
TNKS2 Q9H2K2 4/20 0.33
PARP1 P09874 2/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
CSNK1A1 P48729 1/20 0.32
CSNK1D P48730 1/20 0.32
RPS6KA3 P51812 1/20 0.32
HTR2A P28223 1/20 0.31
GRM2 Q14416 1/20 0.31
AKR1B10 O60218 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2741558 0.90 ESR2 (0.44) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL13614719 0.90 FASN (0.43) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL13447437 0.89 ESR2 (0.42) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL24661359 0.87 AKR1C3 (0.43) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL16280876 0.87 ESR2 (0.44) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL2741559 0.87 ESR2 (0.44) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL13614717 0.86 FASN (0.40) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL18866828 0.86 CYP3A4 (0.46) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL19493506 0.86 CYP3A4 (0.43) ESR2CYP3A4CYP2C9APPCYP2D6
SCHEMBL10091213 0.86 CYP3A4 (0.46) ESR2CYP3A4CYP2C9APPCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2123623-A1 LIQUID CRYSTALLINE COMPOUND, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY ELEMENT Chisso Corporation (JP) 2009-11-25 EP disclosed