Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.56 |
| ▸ | JAK3 | P52333 | 16/20 | 0.56 |
| ▸ | JAK2 | O60674 | 11/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105171 | 0.85 | JAK2 (0.77) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL13398188 | 0.73 | JAK2 (0.63) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105134 | 0.72 | JAK2 (1.00) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105933 | 0.72 | JAK2 (1.00) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105652 | 0.72 | JAK2 (0.75) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL13636626 | 0.71 | JAK3 (0.37) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2102224 | 0.71 | JAK3 (0.81) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105647 | 0.71 | JAK2 (0.78) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105006 | 0.71 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105604 | 0.71 | JAK2 (0.73) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123651-A1 | CONDENSED PYRIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-25 | — | — | EP | disclosed |