Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593824 | 0.81 | PPARG (0.51) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13637196 | 0.81 | KDM4E (0.53) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13440569 | 0.81 | KDM4E (0.51) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13637276 | 0.80 | PPARG (0.46) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13637273 | 0.80 | PPARD (0.48) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13440568 | 0.79 | KDM4E (0.52) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13441819 | 0.76 | KDM4E (0.50) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13637161 | 0.76 | PPARD (0.42) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL13637277 | 0.76 | KDM4E (0.46) | PPARDPPARAPPARGALDH1A1KDM4E | |
| SCHEMBL3587102 | 0.75 | TDP1 (0.49) | PPARDPPARAPPARGALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |