Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.36 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13212850 | 0.84 | PIK3CD (0.36) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2919130 | 0.83 | PIK3CD (0.42) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2916920 | 0.82 | CCNA2 (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2916277 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13212961 | 0.71 | KDM4C (0.35) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2917847 | 0.70 | CCNA2 (0.49) | MEN1KMT2AGABRPGABRDGABRA1 | |
| SCHEMBL2910728 | 0.70 | CCNA2 (0.41) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2915406 | 0.69 | CCNA2 (0.49) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1874008 | 0.66 | PTGS1 (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2910980 | 0.65 | PIK3CD (0.51) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |