Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 14/20 | 0.67 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13631728 | 1.00 | HCAR2 (0.67) | HCAR2HSD17B1KDM4EMEN1MAPT | |
| SCHEMBL13638224 | 0.99 | HCAR2 (0.65) | HCAR2HSD17B1KDM4EMEN1MAPT | |
| SCHEMBL13673279 | 0.99 | HCAR2 (0.65) | HCAR2HSD17B1KDM4EMEN1MAPT | |
| SCHEMBL13631734 | 0.99 | HCAR2 (0.65) | HCAR2HSD17B1KDM4EMEN1MAPT | |
| SCHEMBL13631695 | 0.96 | HCAR2 (0.60) | HCAR2HSD17B1KDM4EMEN1MAPT | |
| SCHEMBL13631729 | 0.80 | HCAR2 (1.00) | HCAR2 | |
| SCHEMBL13638166 | 0.80 | HCAR2 (1.00) | HCAR2 | |
| SCHEMBL13631736 | 0.79 | HCAR2 (0.97) | HCAR2 | |
| SCHEMBL13638167 | 0.79 | HCAR2 (0.97) | HCAR2 | |
| SCHEMBL4479606 | 0.78 | HCAR2 (0.44) | HCAR2HSD17B1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612106-B2 | Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |