Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 20/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 19/20 | 0.64 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.55 |
| ▸ | PTGFR | P43088 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12808616 | 0.89 | PTGDR (0.80) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13176193 | 0.81 | PTGDR (0.81) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13176191 | 0.81 | PTGDR (0.81) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL992456 | 0.77 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL18269300 | 0.75 | PTGDR (0.84) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL13638151 | 0.74 | TBXA2R (0.51) | PTGDRTBXA2R | |
| SCHEMBL12676041 | 0.72 | TBXA2R (0.59) | PTGDRTBXA2R | |
| SCHEMBL13638152 | 0.71 | PTGDR (0.61) | PTGDRTBXA2R | |
| SCHEMBL1253026 | 0.71 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 | |
| SCHEMBL4548353 | 0.71 | PTGDR (1.00) | PTGDRTBXA2RPTGER1PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612106-B2 | Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |