Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 18/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12161374 | 0.93 | P2RY12 (0.40) | ATMWEE1 | |
| SCHEMBL13638705 | 0.90 | ATM (0.43) | ATM | |
| SCHEMBL12177095 | 0.90 | P2RY12 (0.34) | ORAI1 | |
| SCHEMBL9923192 | 0.87 | HRH3 (0.36) | — | |
| SCHEMBL12177096 | 0.87 | ATM (0.41) | ATMWEE1 | |
| SCHEMBL13638605 | 0.87 | KMT2A (0.38) | ATM | |
| SCHEMBL14113580 | 0.87 | WEE1 (0.38) | ATMWEE1 | |
| SCHEMBL9922536 | 0.85 | P2RY12 (0.42) | WEE1 | |
| SCHEMBL13182891 | 0.84 | RAD52 (0.40) | — | |
| SCHEMBL12161316 | 0.84 | P2RY12 (0.46) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |