Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 7/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 7/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.37 |
| ▸ | GRIK4 | Q16099 | 5/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923275 | 0.92 | P2RY12 (0.44) | ARGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL12177433 | 0.89 | P2RY12 (0.41) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL12177436 | 0.89 | ERCC1 (0.40) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL14113556 | 0.85 | AR (0.40) | ARERCC1FEN1ERCC4P2RY12 | |
| SCHEMBL14228647 | 0.84 | P2RY12 (0.52) | ARGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL13182836 | 0.83 | P2RY12 (0.40) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL9923272 | 0.82 | P2RY12 (0.44) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL14228582 | 0.81 | RXFP1 (0.38) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL9923013 | 0.81 | P2RY12 (0.49) | ERCC1FEN1ERCC4P2RY12CA9 | |
| SCHEMBL9923009 | 0.80 | P2RY12 (0.44) | ARGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |