Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | CCNK | O75909 | 5/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.51 |
| ▸ | CDK9 | P50750 | 5/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.51 |
| ▸ | RET | P07949 | 8/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | CDC7 | O00311 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.42 |
| ▸ | PIM1 | P11309 | 4/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477635 | 0.86 | CDK2 (0.51) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638552 | 0.77 | RET (0.40) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638493 | 0.76 | EGFR (0.41) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL3477789 | 0.74 | CDK2 (0.41) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638600 | 0.74 | MAPK8 (0.39) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638546 | 0.74 | RET (0.46) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638685 | 0.73 | CDK7 (0.49) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638449 | 0.72 | CDK2 (0.39) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL13638549 | 0.72 | RET (0.46) | CDK2CCNKCCNE1CDK12CDK9 | |
| SCHEMBL4478873 | 0.72 | RET (0.43) | CDK2CCNKCCNE1CDK12CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |
| US-20070043048-A1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043048-A1 | 2-Aminopyrimidine derivatives and their medical use | TPMT, IKBKB, CHUK | CDK2 77/4885CCNK 1085/4885CCNE1 1410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.