Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638512 | 0.91 | P2RY12 (0.57) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922358 | 0.91 | P2RY12 (0.45) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922937 | 0.91 | P2RY12 (0.57) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922155 | 0.90 | P2RY12 (0.59) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922158 | 0.90 | P2RY12 (0.55) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL12177377 | 0.89 | P2RY12 (0.44) | P2RY12PPARGFBP1NPC1MAPT | |
| SCHEMBL9922163 | 0.89 | P2RY12 (0.54) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922153 | 0.88 | P2RY12 (0.54) | P2RY12TP53HPDPPARGMAPT | |
| SCHEMBL12161433 | 0.88 | P2RY12 (0.54) | P2RY12TP53HDAC1HDAC2HDAC10 | |
| SCHEMBL9922940 | 0.88 | P2RY12 (0.54) | P2RY12TP53HPDPPARGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |