Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177308 | 0.91 | EGLN3 (0.36) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL14228582 | 0.89 | RXFP1 (0.38) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL9922402 | 0.83 | EGLN3 (0.40) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL12177256 | 0.83 | ERCC1 (0.36) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL14200892 | 0.81 | P2RY12 (0.42) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL13638516 | 0.81 | P2RY12 (0.38) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL12177436 | 0.80 | ERCC1 (0.40) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL12177309 | 0.79 | P2RY12 (0.38) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL13182836 | 0.79 | P2RY12 (0.40) | ERCC1FEN1ERCC4CA12CA9 | |
| SCHEMBL12177433 | 0.78 | P2RY12 (0.41) | ERCC1FEN1ERCC4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |