Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 6/20 | 0.35 |
| ▸ | CA9 | Q16790 | 6/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14228250 | 0.92 | P2RY12 (0.50) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922282 | 0.91 | P2RY12 (0.43) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922284 | 0.89 | P2RY12 (0.42) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922204 | 0.88 | KMT2A (0.39) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922581 | 0.87 | P2RY12 (0.41) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922293 | 0.87 | P2RY12 (0.40) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL9922586 | 0.86 | P2RY12 (0.40) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL13182775 | 0.86 | P2RY12 (0.40) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL13182776 | 0.84 | P2RY12 (0.39) | P2RY12MEN1KMT2ACA12CA9 | |
| SCHEMBL14113671 | 0.84 | P2RY12 (0.46) | P2RY12MEN1KMT2ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |