Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922190 | 0.92 | KMT2A (0.40) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL12161591 | 0.92 | KMT2A (0.40) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL9922204 | 0.90 | KMT2A (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL12161583 | 0.90 | KMT2A (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL9922611 | 0.90 | KMT2A (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL9922215 | 0.90 | SCN5A (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL9922612 | 0.90 | KMT2A (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL12161587 | 0.90 | MEN1 (0.39) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL12161586 | 0.89 | MEN1 (0.38) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL9922198 | 0.88 | MEN1 (0.39) | MEN1KMT2ALMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |