Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 15/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922975 | 0.92 | P2RY12 (0.42) | P2RY12PTGER3CA12CA1CA9 | |
| SCHEMBL12161536 | 0.90 | P2RY12 (0.43) | P2RY12PTGER3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9922465 | 0.89 | P2RY12 (0.53) | P2RY12CA12CA1CA9ALDH1A1 | |
| SCHEMBL12161526 | 0.88 | P2RY12 (0.42) | P2RY12PTGER3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14228353 | 0.88 | P2RY12 (0.42) | P2RY12PTGER3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12161535 | 0.87 | GAA (0.44) | P2RY12PTGER3KDM4EALDH1A1LMNA | |
| SCHEMBL12161531 | 0.87 | P2RY12 (0.41) | P2RY12PTGER3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12177655 | 0.87 | P2RY12 (0.38) | P2RY12CA12CA1CA9FBP1 | |
| SCHEMBL12161530 | 0.87 | P2RY12 (0.41) | P2RY12PTGER3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12161546 | 0.87 | ESRRA (0.43) | P2RY12PTGER3CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |