Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 6/20 | 0.36 |
| ▸ | CA9 | Q16790 | 6/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177070 | 0.93 | P2RY12 (0.48) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL12177269 | 0.92 | P2RY12 (0.46) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL14228330 | 0.90 | P2RY12 (0.45) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL14228336 | 0.90 | P2RY12 (0.45) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL12177065 | 0.90 | P2RY12 (0.53) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL14228335 | 0.90 | P2RY12 (0.44) | P2RY12FBP1MAPT | |
| SCHEMBL14228471 | 0.89 | P2RY12 (0.44) | P2RY12FBP1MAPTCA12CA9 | |
| SCHEMBL13638497 | 0.88 | P2RY12 (0.43) | P2RY12FBP1MAPTMEN1KMT2A | |
| SCHEMBL12177236 | 0.88 | P2RY12 (0.43) | P2RY12FBP1MAPTLMNAMEN1 | |
| SCHEMBL14228472 | 0.88 | P2RY12 (0.43) | P2RY12FBP1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |