Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 3/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923001 | 0.92 | P2RY12 (0.46) | P2RY12POLBWEE1TRPV1MAPT | |
| SCHEMBL14228581 | 0.90 | P2RY12 (0.42) | P2RY12BTKWEE1BRD4CREBBP | |
| SCHEMBL13638640 | 0.89 | P2RY12 (0.38) | P2RY12BTKBRD4CREBBPCSF1R | |
| SCHEMBL14228650 | 0.88 | P2RY12 (0.38) | P2RY12BTKWEE1IDH1TRPV1 | |
| SCHEMBL12177675 | 0.84 | P2RY12 (0.41) | P2RY12BTKBRD4CREBBPCSF1R | |
| SCHEMBL9923003 | 0.82 | P2RY12 (0.46) | P2RY12BTKCSF1RMAPTCA9 | |
| SCHEMBL14228651 | 0.82 | P2RY12 (0.39) | P2RY12BTKCSF1RMAPTCA9 | |
| SCHEMBL9922343 | 0.82 | P2RY12 (0.51) | P2RY12BTKCSF1RMAPT | |
| SCHEMBL9923194 | 0.81 | P2RY12 (0.47) | P2RY12CSF1RMAPTCA9CA12 | |
| SCHEMBL9923006 | 0.81 | P2RY12 (0.46) | P2RY12WEE1TRPV1CSF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |