Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922991 | 0.94 | P2RY12 (0.51) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9922986 | 0.91 | P2RY12 (0.51) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9922980 | 0.89 | P2RY12 (0.47) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9922982 | 0.87 | P2RY12 (0.52) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9923173 | 0.87 | P2RY12 (0.64) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12177673 | 0.86 | P2RY12 (0.52) | P2RY12MEN1KMT2AMAPTERCC1 | |
| SCHEMBL9922984 | 0.85 | P2RY12 (0.48) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12177355 | 0.82 | P2RY12 (0.57) | P2RY12MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9922532 | 0.82 | P2RY12 (0.47) | P2RY12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9922892 | 0.81 | P2RY12 (0.69) | P2RY12MEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |