Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638606 | 0.82 | MEN1 (0.67) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL4512246 | 0.80 | CCNA2 (0.61) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL25278128 | 0.80 | MEN1 (0.80) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL4469318 | 0.80 | MEN1 (0.84) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL13638608 | 0.79 | CDK5 (0.55) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL4469916 | 0.79 | MEN1 (0.56) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL25223674 | 0.79 | MEN1 (0.68) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL25609929 | 0.79 | MEN1 (0.68) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL4473389 | 0.78 | CCNA2 (0.67) | MEN1KMT2ANPC1CDK5CDK5R1 | |
| SCHEMBL4466121 | 0.78 | MEN1 (0.80) | MEN1KMT2ANPC1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | MEN1 2737/4885KMT2A 2234/4885NPC1 2068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.