Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | POLR1A | O95602 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.34 |
| ▸ | DNMT3L | Q9UJW3 | 4/20 | 0.34 |
| ▸ | DNMT3A | Q9Y6K1 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923110 | 0.94 | P2RY12 (0.38) | KITEPHX2JAK2JAK3JAK1 | |
| SCHEMBL9922865 | 0.93 | EPHX2 (0.38) | KITEPHX2JAK2JAK3JAK1 | |
| SCHEMBL12177207 | 0.90 | EPHX2 (0.41) | EPHX2HRH3POLR1ANPSR1HTR3A | |
| SCHEMBL9922047 | 0.88 | RPS6KB1 (0.35) | JAK2JAK3JAK1TYK2POLR1A | |
| SCHEMBL9923107 | 0.88 | EPHX2 (0.40) | EPHX2JAK2JAK3JAK1TYK2 | |
| SCHEMBL9922222 | 0.88 | EPHX2 (0.40) | EPHX2JAK2JAK3JAK1TYK2 | |
| SCHEMBL12177281 | 0.86 | EPHX2 (0.43) | KITEPHX2HRH3POLR1ANPSR1 | |
| SCHEMBL9922264 | 0.84 | P2RY12 (0.45) | EPHX2HTR3A | |
| SCHEMBL12177178 | 0.84 | EPHX2 (0.43) | EPHX2 | |
| SCHEMBL9922051 | 0.83 | P2RY12 (0.38) | KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |