Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923149 | 0.92 | P2RY12 (0.59) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9922877 | 0.91 | P2RY12 (0.58) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL12161123 | 0.90 | P2RY12 (0.57) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9922526 | 0.90 | P2RY12 (0.56) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9922674 | 0.89 | P2RY12 (0.55) | P2RY12 | |
| SCHEMBL9923148 | 0.88 | P2RY12 (0.55) | P2RY12 | |
| SCHEMBL9922512 | 0.88 | P2RY12 (0.65) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9922506 | 0.88 | P2RY12 (0.60) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9923147 | 0.88 | P2RY12 (0.54) | P2RY12HTTKDM4EFBP1ERCC1 | |
| SCHEMBL9922881 | 0.88 | P2RY12 (0.52) | P2RY12HTTKDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |